Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000697)
Formula
SVG example
Reactant CPC-211 Product Oxalate
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000699 CPC-211 Glyoxylate Unclear CPC-211 [1], [2]
MR000698 CPC-211 Monochloroacetate(MCA) Unclear CPC-211 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007014 Glyoxylate Oxalate Unclear Glyoxylate [3]
MR001862 Oxaliplatin Oxalate Unclear Oxaliplatin [4], [5], [6], [7]
References
1 Determination of dichloroacetate and its metabolites in human plasma by gas chromatography-mass spectrometry J Chromatogr B Biomed Sci Appl. 1997 Dec 5;703(1-2):75-84. doi: 10.1016/s0378-4347(97)00404-0.
2 Personalized dosing of dichloroacetate using GSTZ1 clinical genotyping assay. Genet Test Mol Biomarkers. 2018 Apr;22(4):266-269.
3 Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism. Biochem J. 2009 Aug 13;422(2):265-72.
4 Roles of Transient Receptor Potential Ankyrin 1 in Oxaliplatin-Induced Peripheral Neuropathy Biol Pharm Bull. 2017;40(7):947-953. doi: 10.1248/bpb.b17-00243.
5 Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion. Molecules. 2023 Apr 4;28(7):3206. doi: 10.3390/molecules28073206.
6 Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/-Lactoglobulin Adduct. Pharmaceuticals (Basel). 2022 Mar 30;15(4):425. doi: 10.3390/ph15040425.
7 Nano-scale imaging of dual stable isotope labeled oxaliplatin in human colon cancer cells reveals the nucleolus as a putative node for therapeutic effect. Nanoscale Adv. 2020 Nov 26;3(1):249-262. doi: 10.1039/d0na00685h.

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