Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000749)
Formula
SVG example
Deamination
Reactant 5-aza-2'-deoxycytidine-monophosphate Product 5-aza-2'-deoxycytidine-diphosphate
Reactant Info Product Info
Metabolic Enzyme Uridine/cytidine monophosphate kinase (UMPK) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000751 Decitabine 5-aza-2'-deoxycytidine-monophosphate Other reaction - Phosphorylation Decitabine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000750 5-aza-2'-deoxycytidine-diphosphate 5-aza-2'-deoxycytidine-triphosphate Other reaction - Phosphorylation Decitabine [2]
References
1 Kinetics of phosphorylation of 5-aza-2'-deoxyycytidine by deoxycytidine kinase Biochem Pharmacol. 1979 Apr 15;28(8):1443-4. doi: 10.1016/0006-2952(79)90454-4.
2 Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase Mol Pharmacol. 1984 May;25(3):436-40.

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