Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000751)
Formula
DCK
SVG example
Phosphorylation
Reactant Decitabine Product 5-aza-2'-deoxycytidine-monophosphate
Reactant Info Product Info
Metabolic Enzyme Deoxycytidine kinase (DCK) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000752 Decitabine 5-aza-2'-deoxyuridine Oxidation - Deamination Decitabine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000749 5-aza-2'-deoxycytidine-monophosphate 5-aza-2'-deoxycytidine-diphosphate Oxidation - Deamination Decitabine [2]
References
1 Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside Biochem Pharmacol. 1983 Apr 1;32(7):1327-8. doi: 10.1016/0006-2952(83)90293-9.
2 Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase Mol Pharmacol. 1984 May;25(3):436-40.

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