Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000755)
Formula
UGT1A3 ...
SVG example
Glucuronidation
Reactant Deferasirox Product Deferasirox metabolite M3
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000754 Deferasirox Deferasirox metabolite M1 Oxidation - Hydroxylation Deferasirox [1], [2]
MR000756 Deferasirox Deferasirox metabolite M2 Oxidation - Hydroxylation Deferasirox [1], [2]
MR000758 Deferasirox Deferasirox metabolite M4 Conjugation - O-Glucuronidation Deferasirox [3]
MR000757 Deferasirox Deferasirox metabolite M6 Conjugation - O-Glucuronidation Deferasirox [1]
References
1 Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state Drug Metab Dispos. 2010 May;38(5):808-16. doi: 10.1124/dmd.109.030833.
2 Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats Drug Metab Dispos. 2008 Dec;36(12):2523-38. doi: 10.1124/dmd.108.022962.
3 Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside Biochem Pharmacol. 1983 Apr 1;32(7):1327-8. doi: 10.1016/0006-2952(83)90293-9.

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