Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000758)
Formula
SVG example
O-Glucuronidation
Reactant Deferasirox Product Deferasirox metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000754 Deferasirox Deferasirox metabolite M1 Oxidation - Hydroxylation Deferasirox [1], [2]
MR000756 Deferasirox Deferasirox metabolite M2 Oxidation - Hydroxylation Deferasirox [1], [2]
MR000755 Deferasirox Deferasirox metabolite M3 Conjugation - Glucuronidation Deferasirox [1]
MR000757 Deferasirox Deferasirox metabolite M6 Conjugation - O-Glucuronidation Deferasirox [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010980 Exjade Exjade Metabolite M4 Oxidation - Hydroxylation Exjade [2]
References
1 Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state Drug Metab Dispos. 2010 May;38(5):808-16. doi: 10.1124/dmd.109.030833.
2 Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats Drug Metab Dispos. 2008 Dec;36(12):2523-38. doi: 10.1124/dmd.108.022962.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.