Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000765)
Formula
SVG example
Deacetylation
Reactant Deflazacort Product 21-Deflazacort
Reactant Info Product Info
Metabolic Type Oxidation - Deacetylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000763 21-Deflazacort 1,2-epoxy-3-OH-21-desDFZ Unclear Deflazacort [1]
MR000760 21-Deflazacort 6alphalpha-OH-21-desDFZ (VI) Unclear Deflazacort [2]
MR000759 21-Deflazacort Deflazacort 6-beta-OH Unclear Deflazacort [2]
MR000761 21-Deflazacort Deflazacort metaboite M397/1 Unclear Deflazacort [1]
MR000762 21-Deflazacort Deflazacort metaboite M401/2 Unclear Deflazacort [1]
MR000764 21-Deflazacort Deflazacort metaboite M417/2 Unclear Deflazacort [1]
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References
1 Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort Pharmacol Res Perspect. 2020 Dec;8(6):e00677. doi: 10.1002/prp2.677.
2 Force degradation behavior of glucocorticoid deflazacort by UPLC: isolation, identification and characterization of degradant by FTIR, NMR and mass analysis J Biomed Res. 2016 Mar;30(2):149-161. doi: 10.7555/JBR.30.20150074.

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