Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000759)
Formula
SVG example
Reactant 21-Deflazacort Product Deflazacort 6-beta-OH
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000765 Deflazacort 21-Deflazacort Oxidation - Deacetylation Deflazacort [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000763 21-Deflazacort 1,2-epoxy-3-OH-21-desDFZ Unclear Deflazacort [2]
MR000760 21-Deflazacort 6alphalpha-OH-21-desDFZ (VI) Unclear Deflazacort [1]
MR000761 21-Deflazacort Deflazacort metaboite M397/1 Unclear Deflazacort [2]
MR000762 21-Deflazacort Deflazacort metaboite M401/2 Unclear Deflazacort [2]
MR000764 21-Deflazacort Deflazacort metaboite M417/2 Unclear Deflazacort [2]
References
1 Force degradation behavior of glucocorticoid deflazacort by UPLC: isolation, identification and characterization of degradant by FTIR, NMR and mass analysis J Biomed Res. 2016 Mar;30(2):149-161. doi: 10.7555/JBR.30.20150074.
2 Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort Pharmacol Res Perspect. 2020 Dec;8(6):e00677. doi: 10.1002/prp2.677.

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