Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000772)
Formula
SVG example
N-Demethylation
Reactant Desvenlafaxine succinate Product N,O-Didesmethylvenlafaxine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000773 Desvenlafaxine succinate Benzyl hydroxy desvenlafaxine Oxidation - Hydroxylation Desvenlafaxine succinate [1]
MR000774 Desvenlafaxine succinate Cyclohexane ring hydroxy desvenlafaxine Oxidation - Hydroxylation Desvenlafaxine succinate [1]
MR000776 Desvenlafaxine succinate Desvenlafaxine N-oxide Oxidation - N-Oxidation Desvenlafaxine succinate [1]
MR000775 Desvenlafaxine succinate Desvenlafaxine O-glucuronide Conjugation - O-Glucuronidation Desvenlafaxine succinate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008963 Desvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - N-demethylation Desvenlafaxine [2]
MR005638 Desvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - N-demethylation Venlafaxine hydrochloride [3], [4], [5]
MR005643 N-Desmethylvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - O-demethylation Venlafaxine hydrochloride [3], [4], [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005640 N,O-Didesmethylvenlafaxine N,N,O-tridesmethylvenlafaxine Oxidation - N-demethylation Venlafaxine hydrochloride [3], [4], [5]
MR005639 N,O-Didesmethylvenlafaxine N,O-didesmethylvenlafaxine glucuronide Conjugation - Glucuronidation Venlafaxine hydrochloride [3], [4], [5]
References
1 DrugBank(Pharmacology-Metabolism)Desvenlafaxine succinate
2 DrugBank(Pharmacology-Metabolism):Desvenlafaxine
3 O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90.
4 Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br J Clin Pharmacol. 1996 Feb;41(2):149-56.
5 Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers

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