Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000777)
Formula
SVG example
Demethylation
Reactant D6alpha-dihydrotetrabenazine Product D3-9-O-Desmethyl-Alpha-Htbz
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000786 Deutetrabenazine D6alpha-dihydrotetrabenazine Unclear Deutetrabenazine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000778 D6alpha-dihydrotetrabenazine D3-10-O-Desmethyl-Alpha-Htbz Oxidation - Demethylation Deutetrabenazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000779 D3-9-O-Desmethyl-Alpha-Htbz Sulfate of O\desmethyl alpha\HTBZ Conjugation - Sulfation Deutetrabenazine [1]
References
1 Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers Clin Transl Sci. 2020 Jul;13(4):707-717. doi: 10.1111/cts.12754.

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