Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000812)
Formula Reactant Dextrorphan Product Dextrorphan sulfate
Reactant Info Product Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000817 Dextromethorphan hydrobromide Dextrorphan Oxidation - O-Demethylation Dextromethorphan hydrobromide [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000811 Dextrorphan 3-hydroxymorphinan Oxidation - N-Demethylation Dextromethorphan hydrobromide [3], [2]
MR000813 Dextrorphan Dextrorphan O-glucuronide Conjugation - Glucuronidation Dextromethorphan hydrobromide [1], [4], [5]
References
1 LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):217-25. doi: 10.1016/j.jchromb.2004.09.040.
2 Classics in Chemical Neuroscience: Dextromethorphan (DXM). ACS Chem Neurosci. 2023 Jun 21;14(12):2256-2270. doi: 10.1021/acschemneuro.3c00088.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
4 Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan. Front Pharmacol. 2022 Oct 24;13:1029073. doi: 10.3389/fphar.2022.1029073.
5 Physiologically-based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups. CPT Pharmacometrics Syst Pharmacol. 2022 Apr;11(4):494-511. doi: 10.1002/psp4.12776.

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