Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000813)
Formula
UGT2B4 ...
SVG example
Glucuronidation
Reactant Dextrorphan Product Dextrorphan O-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000817 Dextromethorphan hydrobromide Dextrorphan Oxidation - O-Demethylation Dextromethorphan hydrobromide [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000811 Dextrorphan 3-hydroxymorphinan Oxidation - N-Demethylation Dextromethorphan hydrobromide [3], [2]
MR000812 Dextrorphan Dextrorphan sulfate Conjugation - Sulfation Dextromethorphan hydrobromide [3]
References
1 LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):217-25. doi: 10.1016/j.jchromb.2004.09.040.
2 Classics in Chemical Neuroscience: Dextromethorphan (DXM). ACS Chem Neurosci. 2023 Jun 21;14(12):2256-2270. doi: 10.1021/acschemneuro.3c00088.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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