Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000831)
Formula
CYP
SVG example
Oxidation
Reactant Diethylstilbestrol Product DES SQ
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000834 Diethylstilbestrol 1-hydroxy-Z,Z-dienestrol Oxidation - Oxidation Diethylstilbestrol [1]
MR000835 Diethylstilbestrol 3'-hydroxy-diethylstilbestro Reduction - Reduction Diethylstilbestrol [1]
MR000832 Diethylstilbestrol Alpha-OH DES Oxidation - Oxidation Diethylstilbestrol [2]
MR000836 Diethylstilbestrol E-DES-3,Coxide Reduction - Reduction Diethylstilbestrol [3]
MR000833 Diethylstilbestrol Z,Z-dienestrol Oxidation - Oxidation Diethylstilbestrol [3], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000829 DES SQ Diethylstilbestrol quinone Oxidation - Oxidation Diethylstilbestrol [2]
References
1 Metabolic activation of diethylstilbestrol and 7,8-benzoflavone in hamster hepatocytes Arch Toxicol Suppl. 1989;13:203-5. doi: 10.1007/978-3-642-74117-3_30.
2 Crude Edible Fig (Ficus carica) Leaf Extract Prevents Diethylstilbestrol (DES)-Induced DNA Strand Breaks in Single-Cell Gel Electrophoresis (SCGE)/Comet Assay: Literature Review and Pilot Study J Bioequivalence Bioavailab. 2019;11(2):19-28. doi: 10.35248/0975-0851.19.11.389.
3 The metabolism of diethylstilbestrol CRC Crit Rev Biochem. 1981;10(3):171-212. doi: 10.3109/10409238109113599.

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