Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000832)
Formula
CYP
SVG example
Oxidation
Reactant Diethylstilbestrol Product Alpha-OH DES
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000834 Diethylstilbestrol 1-hydroxy-Z,Z-dienestrol Oxidation - Oxidation Diethylstilbestrol [1]
MR000835 Diethylstilbestrol 3'-hydroxy-diethylstilbestro Reduction - Reduction Diethylstilbestrol [1]
MR000831 Diethylstilbestrol DES SQ Oxidation - Oxidation Diethylstilbestrol [2]
MR000836 Diethylstilbestrol E-DES-3,Coxide Reduction - Reduction Diethylstilbestrol [3]
MR000833 Diethylstilbestrol Z,Z-dienestrol Oxidation - Oxidation Diethylstilbestrol [3], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000830 Alpha-OH DES Alpha-OSO3 DES Conjugation - Conjugation Diethylstilbestrol [2]
References
1 Metabolic activation of diethylstilbestrol and 7,8-benzoflavone in hamster hepatocytes Arch Toxicol Suppl. 1989;13:203-5. doi: 10.1007/978-3-642-74117-3_30.
2 Crude Edible Fig (Ficus carica) Leaf Extract Prevents Diethylstilbestrol (DES)-Induced DNA Strand Breaks in Single-Cell Gel Electrophoresis (SCGE)/Comet Assay: Literature Review and Pilot Study J Bioequivalence Bioavailab. 2019;11(2):19-28. doi: 10.35248/0975-0851.19.11.389.
3 The metabolism of diethylstilbestrol CRC Crit Rev Biochem. 1981;10(3):171-212. doi: 10.3109/10409238109113599.

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