Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000844)
Formula
CYP
SVG example
Oxidation
Reactant Digitoxin Product Digitoxigenin-bisdigitoxoside
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000842 Digitoxin Digitoxigenin Unclear Digitoxin [1]
MR000845 Digitoxin Digitoxigenin-monodigitoxoside Oxidation - Oxidation Digitoxin [2]
MR000847 Digitoxin Digoxin Unclear Digitoxin [1]
MR000843 Digitoxin Dihydrodigitoxin Unclear Digitoxin [1]
MR000846 Digitoxin Epidigitoxigenin Unclear Digitoxin [3]
References
1 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760
2 Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin. Mol Pharmacol. 1991 Nov;40(5):859-67.
3 Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY:Elsevier Science Publishing Co., Inc. 1988., p. 201

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