Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001022)
Formula
SVG example
Methyl Hydroxylation
Reactant Fentanyl citrate Product Hydroxyfentanyl
Reactant Info Product Info
Metabolic Type Oxidation - Methyl Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001025 Fentanyl citrate . Unclear Fentanyl citrate [1]
MR001024 Fentanyl citrate Despropionylfentanyl Hydrolysis - Amide Hydrolysis Fentanyl citrate [2], [3]
MR001023 Fentanyl citrate Norfentanyl Oxidation - N-Dealkylation Fentanyl citrate [2], [4], [5], [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001021 Hydroxyfentanyl Hydroxynorfentanyl Oxidation - Dealkylation Fentanyl citrate [2]
References
1 Drug Interactions Flockhart Table:Docetaxel
2 Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J Anal Toxicol. 2005 Oct;29(7):590-8.
3 Detecting Fentanyl Analogs in Urine Using Precursor Ion Scan Mode. J Anal Toxicol. 2021 Jan 8:bkab002. doi: 10.1093/jat/bkab002.
4 Fentanyl Absorption, Distribution, Metabolism, and Excretion: Narrative Review and Clinical Significance Related to Illicitly Manufactured Fentanyl. J Addict Med. 2023 May 17. doi: 10.1097/ADM.0000000000001185.
5 Predictors of the Rate of Illicit Fentanyl Metabolism in a Cohort of Pregnant Individuals. J Addict Med. 2023 Jan-Feb 01;17(1):85-88. doi: 10.1097/ADM.0000000000001043.
6 Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC-MS/MS. J Appl Lab Med. 2022 Jun 30;7(4):854-862. doi: 10.1093/jalm/jfac009.

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