Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001023)
Formula
CYP3A4 ...
SVG example
N-Dealkylation
Reactant Fentanyl citrate Product Norfentanyl
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001025 Fentanyl citrate . Unclear Fentanyl citrate [1]
MR001024 Fentanyl citrate Despropionylfentanyl Hydrolysis - Amide Hydrolysis Fentanyl citrate [2], [3]
MR001022 Fentanyl citrate Hydroxyfentanyl Oxidation - Methyl Hydroxylation Fentanyl citrate [2]
References
1 Drug Interactions Flockhart Table:Docetaxel
2 Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J Anal Toxicol. 2005 Oct;29(7):590-8.
3 Detecting Fentanyl Analogs in Urine Using Precursor Ion Scan Mode. J Anal Toxicol. 2021 Jan 8:bkab002. doi: 10.1093/jat/bkab002.

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