Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001119)
Formula
SVG example
Deamination
Reactant Gemcitabine Monophosphate Product 2',2'-difluorodeoxyuridine monophosphate
Reactant Info Product Info
Metabolic Enzyme Deoxycytidylate deaminase (DCTD) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001121 Gemcitabine Gemcitabine Monophosphate Other reaction - Phosphorylation Gemcitabine [1], [2]
MR012329 DFdC DFdCMP Unclear - Unclear CO-101 [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001118 Gemcitabine Monophosphate Gemcitabine diphosphate Other reaction - Phosphorylation Gemcitabine [4]
MR012330 DFdCMP DFdCDP Unclear - Unclear CO-101 [3]
MR012332 DFdCMP DFdUMP Unclear - Unclear CO-101 [3]
References
1 Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective Cancer Chemother Pharmacol. 2016 Jul;78(1):1-12. doi: 10.1007/s00280-016-3003-0.
2 Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer Drugs. 1997 Sep;54(3):447-72. doi: 10.2165/00003495-199754030-00009.
3 Phase I study of oral CP-4126, a gemcitabine derivative, in patients with advanced solid tumors
4 Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides Br J Clin Pharmacol. 2018 Jun;84(6):1279-1289. doi: 10.1111/bcp.13557.

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