Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012329)
Formula Reactant DFdC Product DFdCMP
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012328 Gemcitabine DFdC Unclear - Unclear CO-101 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012333 DFdC DFdU Unclear - Unclear CO-101 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001121 Gemcitabine Gemcitabine Monophosphate Other reaction - Phosphorylation Gemcitabine [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001119 Gemcitabine Monophosphate 2',2'-difluorodeoxyuridine monophosphate Oxidation - Deamination Gemcitabine [4]
MR001118 Gemcitabine Monophosphate Gemcitabine diphosphate Other reaction - Phosphorylation Gemcitabine [5]
MR012330 DFdCMP DFdCDP Unclear - Unclear CO-101 [1]
MR012332 DFdCMP DFdUMP Unclear - Unclear CO-101 [1]
References
1 Phase I study of oral CP-4126, a gemcitabine derivative, in patients with advanced solid tumors
2 Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective Cancer Chemother Pharmacol. 2016 Jul;78(1):1-12. doi: 10.1007/s00280-016-3003-0.
3 Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer Drugs. 1997 Sep;54(3):447-72. doi: 10.2165/00003495-199754030-00009.
4 LC-MS/MS method for quantitation of gemcitabine and its metabolite 2',2'-difluoro-2'-deoxyuridine in mouse plasma and brain tissue: Application to a preclinical pharmacokinetic study J Pharm Biomed Anal. 2021 May 10;198:114025. doi: 10.1016/j.jpba.2021.114025.
5 Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides Br J Clin Pharmacol. 2018 Jun;84(6):1279-1289. doi: 10.1111/bcp.13557.

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