Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001128)
Formula Reactant Glasdegib metabolite M3 Product Glasdegib metabolite M7
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001132 Glasdegib Glasdegib metabolite M3 Oxidation - Demethylation Glasdegib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001129 Glasdegib metabolite M3 Glasdegib metabolite M10 Oxidation - Oxidation Glasdegib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001130 Glasdegib metabolite M8 Glasdegib metabolite M7 Conjugation - Glucuronidation Glasdegib [1]
References
1 Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076.
2 DrugBank(Pharmacology-Metabolism)Glasdegib

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