Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001129)
Formula	Oxidation
	Reactant	Glasdegib metabolite M3	Product	Glasdegib metabolite M10
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001132	Glasdegib	Glasdegib metabolite M3	Oxidation - Demethylation	Glasdegib	[1]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001128	Glasdegib metabolite M3	Glasdegib metabolite M7	Conjugation - Glucuronidation	Glasdegib	[1], [2]

References
1	Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076.
2	DrugBank(Pharmacology-Metabolism)Glasdegib

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