Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001136)
Formula Reactant Glasdegib Product Glasdegib metabolite M11
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001134 Glasdegib Glasdegib metabolite M1,9 Oxidation - Oxidation Glasdegib [1]
MR001138 Glasdegib Glasdegib metabolite M2 Unclear Glasdegib [1]
MR001132 Glasdegib Glasdegib metabolite M3 Oxidation - Demethylation Glasdegib [1]
MR001137 Glasdegib Glasdegib metabolite M4 Oxidation - Oxidation Glasdegib [1]
MR001135 Glasdegib Glasdegib metabolite M6 Oxidation - Glucuronidation; Oxidation Glasdegib [1]
MR001133 Glasdegib Glasdegib metabolite M8 Conjugation - Glucuronidation Glasdegib [1]
References
1 Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076.

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