Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001140)
Formula
SVG example
Hydroxylation
Reactant Glimepiride Product Cyclohexyl hydroxymethyl glimepiride
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001139 Cyclohexyl hydroxymethyl glimepiride Cyclohexyl carboxyl glimepiride Oxidation - Oxidation Glimepiride [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Simultaneous determination of glimepiride and its metabolites in human plasma by liquid chromatography coupled to a tandem mass spectrometry Arch Pharm Res. 2011 Dec;34(12):2073-8. doi: 10.1007/s12272-011-1210-0.

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