Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001154)
Formula
SVG example
Reactant Grepafloxacin Product Grepafloxacin metabolite M2a,2b
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001155 Grepafloxacin Grepafloxacin metabolite M4a,4b Unclear Grepafloxacin [1]
MR001156 Grepafloxacin Grepafloxacin metabolite M6a,6b Unclear Grepafloxacin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001152 Granisetron hydrochloride 9'-desmethylgranisetron Oxidation - Demethylation Granisetron hydrochloride [2]
References
1 Synthesis of possible metabolites of 1-cyclopropyl-1,4-dihydro-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)- 4-oxo-3-quinolinecarboxylic acid (Grepafloxacin, OPC-17116) Chem Pharm Bull (Tokyo). 1995 Dec;43(12):2246-52. doi: 10.1248/cpb.43.2246.
2 Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron. Br J Clin Pharmacol. 1994 Dec;38(6):557-66.

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