Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001152)
Formula
CYP3A4 ...
SVG example
Demethylation
Reactant Granisetron hydrochloride Product 9'-desmethylgranisetron
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001153 Granisetron hydrochloride 7-hydroxygranisetron Oxidation - Hydoxylation Granisetron hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001154 Grepafloxacin Grepafloxacin metabolite M2a,2b Unclear Grepafloxacin [2]
References
1 Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron. Br J Clin Pharmacol. 1994 Dec;38(6):557-66.
2 Synthesis of possible metabolites of 1-cyclopropyl-1,4-dihydro-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)- 4-oxo-3-quinolinecarboxylic acid (Grepafloxacin, OPC-17116) Chem Pharm Bull (Tokyo). 1995 Dec;43(12):2246-52. doi: 10.1248/cpb.43.2246.

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