Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001178)
Formula Reactant Indapamide metabolite M5 Product Indapamide metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001183 Indapamide Indapamide metabolite M5 Oxidation - Oxidation Indapamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001179 Indapamide metabolite M4 Indapamide metabolite M2 Oxidation - Oxidation Indapamide [1]
References
1 Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos. 2009 Mar;37(3):672-84.

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