Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001196)
Formula	Reactant	5-hydroxyindomethacin	Product	5-hydroxyindomethacin glucuronide
Formula	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	UDP-glucuronyltransferase (UGT)				DME Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001200	Indomethacin	5-hydroxyindomethacin	Oxidation - O-Demethylation	Indomethacin	[1]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001197	5-hydroxyindomethacin	5-hydroxyindomethacin sulfate	Conjugation - Sulfation	Indomethacin	[1]

References
1	Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans Biochem Pharmacol. 2013 Apr 15;85(8):1195-202. doi: 10.1016/j.bcp.2013.01.031.

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