Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001228)
Formula Reactant Isoflavone Product Isoflavone glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001230 Isoflavone Isoflavone aglycones Hydrolysis - Hydrolysis Isoflavone [1], [2]
MR001229 Isoflavone Isoflavone sulfate conjugates metabolite Conjugation - Sulfation Isoflavone [1], [2], [3]
References
1 Bioavailability of isoflavones J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):203-10. doi: 10.1016/s1570-0232(02)00347-1.
2 Glucuronides are the main isoflavone metabolites in women J Nutr. 2003 Feb;133(2):399-404. doi: 10.1093/jn/133.2.399.
3 Comprehensive Evaluation of Metabolism and the Contribution of the Hepatic First-Pass Effect in the Bioavailability of Glabridin in Rats. J Agric Food Chem. 2023 Feb 1;71(4):1944-1956. doi: 10.1021/acs.jafc.2c06460.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.