Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001263)
Formula
SVG example
Glucuronidation
Reactant Isotretinoin Product Isotretinoin glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001262 Isotretinoin 4-hydroxy-13-cis-retinoic acid Oxidation - 4-Hydroxylation Isotretinoin [1]
MR001261 Isotretinoin All-trans-retinoic acid Unclear Isotretinoin [2], [3], [1], [4]
References
1 The use of isotretinoin in acne Dermatoendocrinol. 2009 May;1(3):162-9. doi: 10.4161/derm.1.3.9364.
2 Human biliary metabolites of isotretinoin: identification, quantification, synthesis, and biological activity Xenobiotica. 1990 Feb;20(2):193-207. doi: 10.3109/00498259009047155.
3 Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic Drug Metab Dispos. 2022 Jul;50(7):1042-1052. doi: 10.1124/dmd.122.000882.
4 The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther. 2004 May;75(5):464-75.

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