Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001262)
Formula
SVG example
4-Hydroxylation
Reactant Isotretinoin Product 4-hydroxy-13-cis-retinoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - 4-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001261 Isotretinoin All-trans-retinoic acid Unclear Isotretinoin [1], [2], [3], [4]
MR001263 Isotretinoin Isotretinoin glucuronide Conjugation - Glucuronidation Isotretinoin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001258 4-hydroxy-13-cis-retinoic acid 4-oxo-13-cis-retinoic acid Oxidation - Oxidation Isotretinoin [5]
References
1 Human biliary metabolites of isotretinoin: identification, quantification, synthesis, and biological activity Xenobiotica. 1990 Feb;20(2):193-207. doi: 10.3109/00498259009047155.
2 Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic Drug Metab Dispos. 2022 Jul;50(7):1042-1052. doi: 10.1124/dmd.122.000882.
3 The use of isotretinoin in acne Dermatoendocrinol. 2009 May;1(3):162-9. doi: 10.4161/derm.1.3.9364.
4 The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther. 2004 May;75(5):464-75.
5 DrugBank(Pharmacology-Metabolism)Isotretinoin

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