Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001282)
Formula
SVG example
Demethylation
Reactant Ivabradine hydrochloride Product 8-Demethyl Ivabradine
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001281 Ivabradine hydrochloride 7-Demethyl Ivabradine Oxidation - Demethylation Ivabradine hydrochloride [1]
MR001283 Ivabradine hydrochloride Dehydro Ivabradine Unclear Ivabradine hydrochloride [1]
MR001280 Ivabradine hydrochloride N-desmethylivabradine Oxidation - N-Demethylation Ivabradine hydrochloride [1]
References
1 Simultaneous determination of ivabradine and its metabolites in human plasma by liquid chromatography--tandem mass spectrometry J Chromatogr B Biomed Sci Appl. 2000 Aug 18;745(2):261-9. doi: 10.1016/s0378-4347(00)00275-9.

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