Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001280)
Formula
SVG example
N-Demethylation
Reactant Ivabradine hydrochloride Product N-desmethylivabradine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001281 Ivabradine hydrochloride 7-Demethyl Ivabradine Oxidation - Demethylation Ivabradine hydrochloride [1]
MR001282 Ivabradine hydrochloride 8-Demethyl Ivabradine Oxidation - Demethylation Ivabradine hydrochloride [1]
MR001283 Ivabradine hydrochloride Dehydro Ivabradine Unclear Ivabradine hydrochloride [1]
References
1 Simultaneous determination of ivabradine and its metabolites in human plasma by liquid chromatography--tandem mass spectrometry J Chromatogr B Biomed Sci Appl. 2000 Aug 18;745(2):261-9. doi: 10.1016/s0378-4347(00)00275-9.

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