Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001287)
Formula
SVG example
O-Demethylation
Reactant Ivermectin Product 3''-O-Desmethyl-ivermectin B1a
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001289 Ivermectin 3''-O-Desmethyl-ivermectin B1b Oxidation - O-Demethylation Ivermectin [1]
MR001288 Ivermectin 3''\O\demethyl, 4\hydroxymethyl ivermectin Unclear Ivermectin [1]
MR001291 Ivermectin Ivermectin metabolite M2 Unclear Ivermectin [1]
MR001290 Ivermectin Ivermectin metabolite M3 Oxidation - Hydroxylation Ivermectin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001284 3''-O-Desmethyl-ivermectin B1a 3''\O\demethyl, 4\hydroxymethyl ivermectin Unclear Ivermectin [1], [2], [3]
References
1 Identification of the metabolites of ivermectin in humans Pharmacol Res Perspect. 2021 Feb;9(1):e00712. doi: 10.1002/prp2.712.
2 Ivermectin metabolites reduce Anopheles survival. Sci Rep. 2023 May 19;13(1):8131. doi: 10.1038/s41598-023-34719-2.
3 Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes. Malar J. 2023 Jun 24;22(1):194. doi: 10.1186/s12936-023-04624-0.

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