Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001299)
Formula
CYP
SVG example
Hydrolysis
Reactant Ixazomib Product Ixazomib metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001301 Ixazomib Ixazomib metabolite M1 Hydrolysis - Hydrolysis Ixazomib [1]
MR001300 Ixazomib Ixazomib metabolite M2 Hydrolysis - Hydrolysis Ixazomib [1]
MR001304 Ixazomib Ixazomib metabolite M20 Oxidation - Oxidation Ixazomib [1]
MR001303 Ixazomib Ixazomib metabolite M3 Hydrolysis - Hydrolysis Ixazomib [1], [2]
MR001302 Ixazomib Ixazomib metabolite M6 Unclear Ixazomib [1]
MR001305 Ixazomib ML790286 Oxidation - Dehydrogenation Ixazomib [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001296 Ixazomib metabolite M5 Ixazomib metabolite M2 Unclear Ixazomib [1]
MR001297 Ixazomib metabolite M5 Ixazomib metabolite M6 Unclear Ixazomib [1]
References
1 Biotransformation of [(14)C]-ixazomib in patients with advanced solid tumors: characterization of metabolite profiles in plasma, urine, and feces Cancer Chemother Pharmacol. 2018 Nov;82(5):803-814. doi: 10.1007/s00280-018-3671-z.
2 Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism Int J Mol Sci. 2021 Oct 27;22(21):11595. doi: 10.3390/ijms222111595.
3 U. S. FDA Label -Ixazomib

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