Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001377)
Formula
SVG example
Reduction
Reactant Ketotifen Product 10alpha-hydroxyl Ketotifen
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001376 Ketotifen Ketotifen-N-glucuronide Conjugation - N-Glucuronidation Ketotifen [1], [2]
MR001378 Ketotifen Nor-ketotifen Oxidation - N-Demethylation Ketotifen [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001375 10alpha-hydroxyl Ketotifen 10alpha-hydroxyl-demethylated Ketotifen Unclear Ketotifen [4]
References
1 N+-glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group Drug Metab Dispos. 1998 Sep;26(9):830-7.
2 Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. Drug Metab Dispos. 2013 Jul;41(7):1389-97.
3 Ketotifen is a Prodrug. Norketotifen is the active metabolite Drug Dev Res. 2022 Apr;83(2):362-367. doi: 10.1002/ddr.21865.
4 Quantification of ketotifen and its metabolites in human plasma by gas chromatography mass spectrometry Biomed Mass Spectrom. 1983 Mar;10(3):136-42. doi: 10.1002/bms.1200100307.

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