Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001378)
Formula
SVG example
N-Demethylation
Reactant Ketotifen Product Nor-ketotifen
Reactant Info Product Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001377 Ketotifen 10alpha-hydroxyl Ketotifen Reduction - Reduction Ketotifen [1]
MR001376 Ketotifen Ketotifen-N-glucuronide Conjugation - N-Glucuronidation Ketotifen [2], [3]
References
1 Quantification of ketotifen and its metabolites in human plasma by gas chromatography mass spectrometry Biomed Mass Spectrom. 1983 Mar;10(3):136-42. doi: 10.1002/bms.1200100307.
2 N+-glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group Drug Metab Dispos. 1998 Sep;26(9):830-7.
3 Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. Drug Metab Dispos. 2013 Jul;41(7):1389-97.

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