Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001386)
Formula Reactant Labetalol Product Labetalol Phenolic glucuronide metabolite (III)
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001389 Labetalol Labetalol 3-hydroxylated metabolite (VI) Oxidation - 3-Hydroxylation Labetalol [1]
MR001385 Labetalol Labetalol Benzyl glucuronide metabolite (II) Conjugation - O-Glucuronidation Labetalol [2], [3]
MR001388 Labetalol Labetalol Hydroxylated metabolite (IV) Oxidation - 4-Hydroxylation Labetalol [1]
MR001387 Labetalol Labetalol N-glucuronide metabolite Conjugation - O-Glucuronidation Labetalol [2], [3]
References
1 Urinary metabolites of (R),(R)-labetalol Drug Metab Dispos. 1994 Nov-Dec;22(6):866-72.
2 Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75.
3 Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes Front Pharmacol. 2021 Apr 15;12:655320. doi: 10.3389/fphar.2021.655320.

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