| General Information of Drug Metabolite (DM) (ID: DM002833) |
| DM Name |
Labetalol Phenolic glucuronide metabolite (III)
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A1 (UGT1A1)
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DME0004
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| Conjugation - O-Glucuronidation |
Labetalol
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[1] , [2] |
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UDP-glucuronosyltransferase 1A9 (UGT1A9)
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DME0042
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| Conjugation - O-Glucuronidation |
Labetalol
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[1] , [2] |
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UDP-glucuronosyltransferase 2B7 (UGT2B7)
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DME0040
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| Conjugation - O-Glucuronidation |
Labetalol
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Labetalol |
DR0909
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Approved |
Essential hypertension |
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| References |
| 1 |
Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75.
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| 2 |
Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes Front Pharmacol. 2021 Apr 15;12:655320. doi: 10.3389/fphar.2021.655320.
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