Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001399)
Formula	CYP3A4 ... Demethylation
	Reactant	Lacosamide		Product	O-Desmethyl-lacosamide
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)					DME Info
	Cytochrome P450 2C9 (CYP2C9)					DME Info
	Mephenytoin 4-hydroxylase (CYP2C19)					DME Info
Metabolic Type	Oxidation - Demethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001400	Lacosamide	Descarbonyl-lacosamide	Unclear	Lacosamide	[1]

References
1	Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration Eur J Drug Metab Pharmacokinet. 2012 Dec;37(4):241-8. doi: 10.1007/s13318-012-0093-x.

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