Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001415)
Formula Reactant Lansoprazole Product Lansoprazole sulfide
Reactant Info Product Info
Metabolic Enzyme Nonenzymatical (Non-ME) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001413 Lansoprazole 5-hydroxylansoprazole Oxidation - Hydroxylation Lansoprazole [1], [2]
MR014191 Lansoprazole AG2000 Free Base Other reaction - Acid environment Lansoprazole [3]
MR001416 Lansoprazole Lansoprazole metabolite M1 Reduction - Reduction Lansoprazole [4]
MR001417 Lansoprazole Lansoprazole metabolite M2 Reduction - Reduction Lansoprazole [4]
MR001414 Lansoprazole Lansoprazole sulfone Oxidation - Sulfoxidation Lansoprazole [1]
References
1 Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther. 1996 May;277(2):805-16.
2 Oxidative metabolism of lansoprazole by human liver cytochromes P450. Mol Pharmacol. 1995 Feb;47(2):410-8.
3 The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels
4 Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 1725

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