Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001416)
Formula Reactant Lansoprazole Product Lansoprazole metabolite M1
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001413 Lansoprazole 5-hydroxylansoprazole Oxidation - Hydroxylation Lansoprazole [1], [2]
MR014191 Lansoprazole AG2000 Free Base Other reaction - Acid environment Lansoprazole [3]
MR001417 Lansoprazole Lansoprazole metabolite M2 Reduction - Reduction Lansoprazole [4]
MR001415 Lansoprazole Lansoprazole sulfide Unclear Lansoprazole [1]
MR001414 Lansoprazole Lansoprazole sulfone Oxidation - Sulfoxidation Lansoprazole [1]
References
1 Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther. 1996 May;277(2):805-16.
2 Oxidative metabolism of lansoprazole by human liver cytochromes P450. Mol Pharmacol. 1995 Feb;47(2):410-8.
3 The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels
4 Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 1725

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