Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001435)
Formula Reactant Lenvatinib mesylate metabolite M2 Product Lenvatinib mesylate metabolite H
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010933 Lenvatinib O-demethyl Lenvatinib Unclear - Unclear Lenvatinib [1]
MR001437 Lenvatinib mesylate Lenvatinib mesylate metabolite M2 Oxidation - Dealkylation Lenvatinib mesylate [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001434 Lenvatinib mesylate metabolite M2 Lenvatinib mesylate metabolite M2' Oxidation - Oxidation Lenvatinib mesylate [2]
References
1 The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2 Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison Invest New Drugs. 2016 Jun;34(3):300-18. doi: 10.1007/s10637-016-0342-y.

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