Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010933)
Formula
CYP1A1 ...
SVG example
Unclear
Reactant Lenvatinib Product O-demethyl Lenvatinib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010932 Lenvatinib Lenvatinib N-oxide Unclear - Unclear Lenvatinib [1]
MR010934 Lenvatinib N-descyclopropyl lenvatinib Unclear - Unclear Lenvatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001437 Lenvatinib mesylate Lenvatinib mesylate metabolite M2 Oxidation - Dealkylation Lenvatinib mesylate [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001435 Lenvatinib mesylate metabolite M2 Lenvatinib mesylate metabolite H Conjugation - Glucuronidation Lenvatinib mesylate [2]
MR001434 Lenvatinib mesylate metabolite M2 Lenvatinib mesylate metabolite M2' Oxidation - Oxidation Lenvatinib mesylate [2]
References
1 The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2 Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison Invest New Drugs. 2016 Jun;34(3):300-18. doi: 10.1007/s10637-016-0342-y.

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