Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001446)
Formula Reactant 4,4'-methanol-bisbenzonitrile Product Letrozole carbinol glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001445 Letrozole ketone analog metabolite 4,4'-methanol-bisbenzonitrile Unclear Letrozole [1]
References
1 Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75.

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