General Information of This Metabolic Reaction (MR) (ID:
MR001446) |
Formula |
Reactant |
4,4'-methanol-bisbenzonitrile |
Product |
Letrozole carbinol glucuronide metabolite |
Reactant Info
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Product Info
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Metabolic Enzyme
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UDP-glucuronosyltransferase 2B7 (UGT2B7)
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DME Info
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Metabolic Type
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Conjugation
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Glucuronidation
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Produce The Reactant of This MR
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References |
1 |
Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75.
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