Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001445)
Formula Reactant Letrozole ketone analog metabolite Product 4,4'-methanol-bisbenzonitrile
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001447 Letrozole Letrozole ketone analog metabolite Unclear Letrozole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001446 4,4'-methanol-bisbenzonitrile Letrozole carbinol glucuronide metabolite Conjugation - Glucuronidation Letrozole [2]
References
1 Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75.
2 The letrozole phase 1 metabolite carbinol as a novel probe drug for UGT2B7 Drug Metab Dispos. 2013 Nov;41(11):1906-13. doi: 10.1124/dmd.113.053405.

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