Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001461)
Formula Reactant Levobunolol Product Levobunolol metabolite M11
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 1 (CBR1) DME Info
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info
Aldo-keto reductase 1B1 (AKR1B1) DME Info
DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001463 Levobunolol Hydroxy-LB Oxidation - Hydroxylation Levobunolol [1]
MR001462 Levobunolol Levobunolol metabolite M10 Oxidation - Oxidation Levobunolol [1]
MR001466 Levobunolol Levobunolol metabolite M12 Oxidation - Dihydroxylation Levobunolol [1]
MR001465 Levobunolol Levobunolol metabolite M13 Oxidation - Monohydroxylation Levobunolol [1]
MR001464 Levobunolol Levobunolol metabolite M9 Oxidation - Monohydroxylation Levobunolol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001454 Levobunolol metabolite M11 Levobunolol metabolite M4 Oxidation - Hydroxylation Levobunolol [1]
MR001455 Levobunolol metabolite M11 Levobunolol metabolite M8 Oxidation - Hydroxylation Levobunolol [1]
References
1 Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways Drug Metab Dispos. 2016 Aug;44(8):1304-12. doi: 10.1124/dmd.116.070458.

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