Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001481)
Formula Reactant Levocetirizine Product Levocetirizine N-dealkylated and Aromatic Hydroxylated metabolite (M9)
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001479 Levocetirizine Levocetirizine Dihydrodiol metabolite (M2) Unclear Levocetirizine [1]
MR001480 Levocetirizine Levocetirizine Hydroxy metabolite (M5) Unclear Levocetirizine [1]
MR001482 Levocetirizine Levocetirizine N-oxide metabolite (M3) Oxidation - N-Oxidation Levocetirizine [1]
MR001483 Levocetirizine Levocetirizine O-dealkylated metabolite (M6) Oxidation - O-Dealkylation Levocetirizine [1]
MR001484 Levocetirizine Levocetirizine Taurine conjugated metabolite (M8) Conjugation - Taurine Conjugation Levocetirizine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001478 Levocetirizine N-dealkylated and Aromatic Hydroxylated metabolite (M9) Levocetirizine 4-chloro-4'-hydroxybenzhydryl Mercapturate metabolites (M10a and M10b) Unclear Levocetirizine [1]
References
1 Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers Eur J Clin Pharmacol. 2001 Oct;57(8):571-82. doi: 10.1007/s002280100364.

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