Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001483)
Formula Reactant Levocetirizine Product Levocetirizine O-dealkylated metabolite (M6)
Reactant Info Product Info
Metabolic Type Oxidation - O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001479 Levocetirizine Levocetirizine Dihydrodiol metabolite (M2) Unclear Levocetirizine [1]
MR001480 Levocetirizine Levocetirizine Hydroxy metabolite (M5) Unclear Levocetirizine [1]
MR001481 Levocetirizine Levocetirizine N-dealkylated and Aromatic Hydroxylated metabolite (M9) Unclear Levocetirizine [1]
MR001482 Levocetirizine Levocetirizine N-oxide metabolite (M3) Oxidation - N-Oxidation Levocetirizine [1]
MR001484 Levocetirizine Levocetirizine Taurine conjugated metabolite (M8) Conjugation - Taurine Conjugation Levocetirizine [1]
References
1 Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers Eur J Clin Pharmacol. 2001 Oct;57(8):571-82. doi: 10.1007/s002280100364.

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