Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001538)
Formula
SVG example
Reactant L-glutamine Product Dihydropteroate
Reactant Info Product Info
Metabolic Enzyme Folylpolyglutamate synthetase (fpgS) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001542 L-glutamine Amino sugars Unclear L-glutamine [1]
MR001539 L-glutamine Glucosamine-6-phosphate Oxidation - Deamination L-glutamine [1]
MR001537 L-glutamine L-glutamate Unclear L-glutamine [2], [3], [4]
MR001540 L-glutamine Purines Unclear L-glutamine [1]
MR001541 L-glutamine Pyrimidines Unclear L-glutamine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001536 Dihydropteroate Dihydrofolate Unclear L-glutamine [5]
References
1 The Emerging Role of l-Glutamine in Cardiovascular Health and Disease Nutrients. 2019 Sep 4;11(9):2092. doi: 10.3390/nu11092092.
2 Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation Nutrients. 2018 Oct 23;10(11):1564. doi: 10.3390/nu10111564.
3 The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications Amino Acids. 2016 Sep;48(9):2067-80. doi: 10.1007/s00726-016-2254-8.
4 Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics - synthesis and properties. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1928-1956. doi: 10.1080/14756366.2022.2096018.
5 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.

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