Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001556)
Formula
AKR
SVG example
Reduction
Reactant Linagliptin CD10604 Product Linagliptin CD1790
Reactant Info Product Info
Metabolic Enzyme Aldo-keto reductases (AKR) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001565 Linagliptin Linagliptin CD10604 Oxidation - Oxidation Linagliptin [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001558 Linagliptin CD1790 Linagliptin M490 Oxidation - Hydroxylation Linagliptin [2]
MR001557 Linagliptin CD1790 Linagliptin M506 Oxidation - Hydroxylation Linagliptin [2]
References
1 Clinical pharmacokinetics and pharmacodynamics of linagliptin Clin Pharmacokinet. 2012 Jul 1;51(7):411-27. doi: 10.2165/11630900-000000000-00000.
2 The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans Drug Metab Dispos. 2010 Apr;38(4):667-78. doi: 10.1124/dmd.109.031476.

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