Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001565)
Formula
SVG example
Oxidation
Reactant Linagliptin Product Linagliptin CD10604
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001570 Linagliptin Linagliptin M487(1) Reduction - Reduction Linagliptin [1]
MR001567 Linagliptin Linagliptin M489(1) Oxidation - Hydroxylation Linagliptin [1]
MR001569 Linagliptin Linagliptin M503(1) Unclear Linagliptin [1]
MR001566 Linagliptin Linagliptin M515 Unclear Linagliptin [1]
MR001571 Linagliptin M665(3) Conjugation - Glucuronidation Linagliptin [1]
MR001572 Linagliptin M665(8) Conjugation - Glucuronidation Linagliptin [1]
MR001568 Linagliptin N-acetylcyteine M636 Conjugation - N-Acetylation Linagliptin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001556 Linagliptin CD10604 Linagliptin CD1790 Reduction - Reduction Linagliptin [1]
References
1 The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans Drug Metab Dispos. 2010 Apr;38(4):667-78. doi: 10.1124/dmd.109.031476.

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